A 2-Substituted Prodiginine, 2-(p-Hydroxybenzyl)prodigiosin, from Pseudoalteromonas rubra

In the course of work aimed at the discovery of new pharmaceutical lead compounds from marine bacteria, a lipophilic extract of the bacterium Pseudoalteromonas rubra displayed significant cytotoxicity against SKOV-3, a human ovarian adenocarcinoma cell line. Bioassay-directed fractionation of this e...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2008-11, Vol.71 (11), p.1970-1972
Main Authors: Fehér, Domonkos, Barlow, Russell S, Lorenzo, Patricia S, Hemscheidt, Thomas K
Format: Article
Language:English
Subjects:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Chemotherapic agents
Fundamental and applied biological sciences. Psychology
Humans
Marine Biology
Microbiology
Molecular Structure
Prodigiosin - analogs & derivatives
Prodigiosin - chemistry
Prodigiosin - metabolism
Pseudoalteromonas - chemistry
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Summary:In the course of work aimed at the discovery of new pharmaceutical lead compounds from marine bacteria, a lipophilic extract of the bacterium Pseudoalteromonas rubra displayed significant cytotoxicity against SKOV-3, a human ovarian adenocarcinoma cell line. Bioassay-directed fractionation of this extract resulted in the isolation of a series of known and new prodiginine-type azafulvenes. The structure of the major metabolite was elucidated by interpretation of spectroscopic data as a 2-substituted prodigiosin, which we named 2-(p-hydroxybenzyl)prodigiosin (HBPG).
ISSN:0163-3864
1520-6025
DOI:10.1021/np800493p