Quantitation of calcium metabolism in postmenopausal osteoporosis and in scoliosis

By a combination of balance and isotope techniques, the following parameters of Ca metabolism were measured: pool size, rate of loss from pool, urinary excretion, fecal excretion, intake, endogenous fecal Ca, absorption, balance, bone formation, and bone resorption. The subjects were two normal wome...

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Bibliographic Details
Published in:The Journal of clinical investigation 1963-06, Vol.42 (6), p.898-905
Main Authors: BRONNER, F, RICHELLE, L J, SAVILLE, P D, NICHOLAS, J A, COBB, J R
Format: Article
Language:English
Subjects:
AGE
BASIC BIOLOGICAL SCIENCES
BONES
CALCIUM
DISEASES
Female
Humans
MAN
MEDICINE
MENOPAUSE
METABOLISM
Old Medline
OSTEOPOROSIS
Osteoporosis, Postmenopausal
QUANTITATIVE ANALYSIS
RADIATION INJURIES
Scoliosis
SEX
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Summary:By a combination of balance and isotope techniques, the following parameters of Ca metabolism were measured: pool size, rate of loss from pool, urinary excretion, fecal excretion, intake, endogenous fecal Ca, absorption, balance, bone formation, and bone resorption. The subjects were two normal women and five women with postmenopausal osteoporosis, aged 41 to 74 years, and four patients with scoliosis, aged 12 to 22 years. The latter were studied before, shortly after, and many months after immobilization in plaster casts. On the basis of observed relationships, it appeared that the negative Ca balance observed in the older women was due to the low intensity of the various vectors of Ca metabolism, without clearcut distinction between the subjects with and without osteoporosis. Conversely, in the young patients with scoliosis, the negative balance incident to treatment by immobilization was associated with vectors of relatively high intensity whose relationships were altered temporarily.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI104782