Subcellular Localization of Thiol-Capped CdTe Quantum Dots in Living Cells

Internalization and dynamic subcellular distribution of thiol-capped CdTe quantum dots (QDs) in living cells were studied by means of laser scanning confocal microscopy. These unfunctionalized QDs were well internalized into human hepatocellular carcinoma and rat basophilic leukemia cells in vitro....

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Bibliographic Details
Published in:Nanoscale research letters 2009-07, Vol.4 (7), p.606-612, Article 606
Main Authors: Zhang, Yu, Mi, Lan, Xiong, Rongling, Wang, Pei-Nan, Chen, Ji-Yao, Yang, Wuli, Wang, Changchun, Peng, Qian
Format: Article
Language:English
Subjects:
Basophilic leukemia
Cadmium tellurides
Cells (biology)
Chemistry and Materials Science
Confocal microscopy
Endocytosis
Endosomes
Golgi apparatus
Hepatocellular carcinoma
Internalization
Leukemia
Localization
Lysosomes
Materials Science
Molecular Medicine
Nano Express
Nanochemistry
Nanoscale Science and Technology
Nanotechnology
Nanotechnology and Microengineering
Quantum dots
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Summary:Internalization and dynamic subcellular distribution of thiol-capped CdTe quantum dots (QDs) in living cells were studied by means of laser scanning confocal microscopy. These unfunctionalized QDs were well internalized into human hepatocellular carcinoma and rat basophilic leukemia cells in vitro. Co-localizations of QDs with lysosomes and Golgi complexes were observed, indicating that in addition to the well-known endosome-lysosome endocytosis pathway, the Golgi complex is also a main destination of the endocytosed QDs. The movement of the endocytosed QDs toward the Golgi complex in the perinuclear region of the cell was demonstrated.
ISSN:1556-276X
1931-7573
1556-276X
DOI:10.1007/s11671-009-9307-9