An interdependent model of central/peripheral chemoreception: Evidence and implications for ventilatory control

Abstract In this review we discuss the implications for ventilatory control of newer evidence suggesting that central and peripheral chemoreceptors are not functionally separate but rather that they are dependent upon one another such that the sensitivity of the medullary chemoreceptors is criticall...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2010-10, Vol.173 (3), p.288-297
Main Authors: Smith, Curtis A, Forster, Hubert V, Blain, Grégory M, Dempsey, Jerome A
Format: Article
Language:English
Subjects:
Animals
Brain
Brain - cytology
Brain - physiology
Carotid Body
Carotid Body - cytology
Carotid Body - metabolism
Chemoreceptor Cells
Chemoreceptor Cells - cytology
Chemoreceptor Cells - metabolism
Chemoreceptors
Human health and pathology
Humans
Hypercapnia
Hypoxia
Interdependence
Life Sciences
Medical Education
Models, Biological
Pulmonary Ventilation
Pulmonary Ventilation - physiology
Pulmonary/Respiratory
Tissues and Organs
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Summary:Abstract In this review we discuss the implications for ventilatory control of newer evidence suggesting that central and peripheral chemoreceptors are not functionally separate but rather that they are dependent upon one another such that the sensitivity of the medullary chemoreceptors is critically determined by input from the carotid body chemoreceptors and vice versa i.e. , they are interdependent. We examine potential interactions of the interdependent central and carotid body (CB) chemoreceptors with other ventilatory-related inputs such as central hypoxia, lung stretch, and exercise. The limitations of current approaches addressing this question are discussed and future studies are suggested.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2010.02.015