MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems

Biological systems are continuously challenged by an environment that is variable. Yet, a key feature of developmental and physiological processes is their remarkable stability. This review considers how microRNAs contribute to gene regulatory networks that confer robustness.

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Bibliographic Details
Published in:Genes & development 2010-07, Vol.24 (13), p.1339-1344
Main Authors: Herranz, Héctor, Cohen, Stephen M
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Epithelial Cells - cytology
Feedback, Physiological
Gene Regulatory Networks - genetics
Genes, Switch - genetics
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
Neurons - cytology
Protein Interaction Domains and Motifs - physiology
Review
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Description
Summary:Biological systems are continuously challenged by an environment that is variable. Yet, a key feature of developmental and physiological processes is their remarkable stability. This review considers how microRNAs contribute to gene regulatory networks that confer robustness.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.1937010