ConSurf 2010: calculating evolutionary conservation in sequence and structure of proteins and nucleic acids

It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often indicative of structural and/or functional importance. ConSurf (http://consurf.tau.ac.il) and ConSeq (http://conseq.tau.ac.il) are two well-established web servers for calculat...

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Bibliographic Details
Published in:Nucleic acids research 2010-07, Vol.38 (Web Server issue), p.W529-W533
Main Authors: Ashkenazy, Haim, Erez, Elana, Martz, Eric, Pupko, Tal, Ben-Tal, Nir
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Base Sequence
Conserved Sequence
Evolution, Molecular
Internet
Nucleic Acid Conformation
Protein Conformation
Sequence Analysis
Sequence Homology, Amino Acid
Software
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Summary:It is informative to detect highly conserved positions in proteins and nucleic acid sequence/structure since they are often indicative of structural and/or functional importance. ConSurf (http://consurf.tau.ac.il) and ConSeq (http://conseq.tau.ac.il) are two well-established web servers for calculating the evolutionary conservation of amino acid positions in proteins using an empirical Bayesian inference, starting from protein structure and sequence, respectively. Here, we present the new version of the ConSurf web server that combines the two independent servers, providing an easier and more intuitive step-by-step interface, while offering the user more flexibility during the process. In addition, the new version of ConSurf calculates the evolutionary rates for nucleic acid sequences. The new version is freely available at: http://consurf.tau.ac.il/.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gkq399