Evaluation of Cytotoxicity and Genotoxicity of Inula viscosa Leaf Extracts with Allium Test

• Published in: BioMed research international 2010-01, Vol.2010 (2010), p.1-8
• Main Authors: Askin Celik, Tuelay, Aslantuerk, Oezlem Sultan
• Format: Article
• Language: English
• Subjects: Allium - cytology; Allium - genetics; Allium cepa; Analysis of Variance; Biological and medical sciences; Biology; Cell Membrane - drug effects; Cell Proliferation - drug effects; Chromosome Aberrations - drug effects; Cytogenetic Analysis; Cytotoxicity; Drinking water; Folk medicine; Herbs; Inula; Inula - chemistry; Leaves; Medical sciences; Medicine; Meristem - cytology; Meristem - genetics; Micronuclei, Chromosome-Defective - drug effects; Mitosis - drug effects; Morphology; Mutagenicity Tests; Pharmacology. Drug treatments; Plant Extracts - toxicity; Plant Leaves - chemistry; Plant Roots - cytology; Toxicity; Variance analysis
• ISSN: 1110-7243; 2314-6133; 1110-7251; 2314-6141
• DOI: 10.1155/2010/189252

I. viscosa has been used for years in folk medicine for its anti-inflammatory, antipyretic, antiseptic, and paper antiphlogistic activities. In this study, cytotoxic and genotoxic effects of I. viscosa leaf extracts on the root meristem cells of Allium cepa have been examined. Onion bulbs were exposed to 2.5 mg/ml, 5 mg/ml, and 10 mg/ml concentrations of the extracts for macroscopic and microscopic analysis. Tap water has been used as a negative control and Ethyl methanesulfonate (EMS) (2⋅10−2 M) has been used as a positive control. The test concentrations have been determined according to doses which are recommended for use in alternative medicine. There has been statistically significant (P