A New Method for the Evaluation of Vaccine Safety Based on Comprehensive Gene Expression Analysis

For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, neces...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2010-01, Vol.2010 (2010), p.1-7
Main Authors: Momose, Haruka, Mizukami, Takuo, Ochiai, Masaki, Hamaguchi, Isao, Yamaguchi, Kazunari
Format: Article
Language:English
Subjects:
Animals
Biological products
Biology
Biomarkers
Biotechnology
Blood
Brain
Cluster Analysis
Disease Models, Animal
Drug Evaluation, Preclinical - methods
Drug Evaluation, Preclinical - standards
Drug Evaluation, Preclinical - trends
Gene expression
Gene Expression Profiling - methods
Genomes
Good Manufacturing Practice
Immunization
Mice
Oligonucleotide Array Sequence Analysis - methods
Quality Control
Rats
Review
Rodents
Safety
Technological change
Toxicity
Toxicology
Vaccines
Vaccines - adverse effects
Vaccines - standards
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:For the past 50 years, quality control and safety tests have been used to evaluate vaccine safety. However, conventional animal safety tests need to be improved in several aspects. For example, the number of test animals used needs to be reduced and the test period shortened. It is, therefore, necessary to develop a new vaccine evaluation system. In this review, we show that gene expression patterns are well correlated to biological responses in vaccinated rats. Our findings and methods using experimental biology and genome science provide an important means of assessment for vaccine toxicity.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2010/361841