Interpreting weight losses from lifestyle modification trials: using categorical data

Although studies in obese subjects using weight loss medications typically report mean and categorical weight loss, results from diet and exercise intervention trials typically only report mean weight change from baseline along with a level of significance. These data alone do not give clinicians or...

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Published in:International Journal of Obesity 2010-01, Vol.34 (1), p.207-209
Main Authors: Christian, J.G, Tsai, A.G, Bessesen, D.H
Format: Article
Language:English
Subjects:
behavior modification
Biological and medical sciences
Body weight loss
Calories
Care and treatment
categorical data
Clinical trials
Clinical Trials as Topic
Data Interpretation, Statistical
Diabetes
Employee benefits
Epidemiology
Gastrointestinal surgery
Health aspects
Health Promotion and Disease Prevention
Humans
Internal Medicine
Intervention
lifestyle
Lifestyles
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity
Obesity - physiopathology
Obesity - therapy
Occupational health
patients
Public Health
Risk Factors
Risk Reduction Behavior
short-communication
Treatment Outcome
Weight control
weight control programs
Weight loss
Weight Loss - physiology
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description Although studies in obese subjects using weight loss medications typically report mean and categorical weight loss, results from diet and exercise intervention trials typically only report mean weight change from baseline along with a level of significance. These data alone do not give clinicians or administrators the data needed to determine the probability that an individual will achieve clinically relevant weight loss. Thus, it is difficult to decide which patients, employees or health plan enrollee would benefit from the type and level of support used in a clinical trial. Our goal was to assess what fraction of subjects enrolled in lifestyle modification interventions achieved clinically significant weight loss. Thus, we requested categorical weight loss data from several investigators who had published results from studies involving either a high- or low-intensity lifestyle modification intervention arm. These categorical data indicate that a substantial fraction of subjects in each lifestyle modification intervention achieved clinically meaningful weight loss, even when the average weight loss is modest.
doi_str_mv 10.1038/ijo.2009.213
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source Nature_系列刊
subjects behavior modification
Biological and medical sciences
Body weight loss
Calories
Care and treatment
categorical data
Clinical trials
Clinical Trials as Topic
Data Interpretation, Statistical
Diabetes
Employee benefits
Epidemiology
Gastrointestinal surgery
Health aspects
Health Promotion and Disease Prevention
Humans
Internal Medicine
Intervention
lifestyle
Lifestyles
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Obesity
Obesity - physiopathology
Obesity - therapy
Occupational health
patients
Public Health
Risk Factors
Risk Reduction Behavior
short-communication
Treatment Outcome
Weight control
weight control programs
Weight loss
Weight Loss - physiology
title Interpreting weight losses from lifestyle modification trials: using categorical data
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