Imaging and Modeling of Myocardial Metabolism

Current imaging methods have focused on evaluation of myocardial anatomy and function. However, since myocardial metabolism and function are interrelated, metabolic myocardial imaging techniques, such as positron emission tomography, single photon emission tomography, and magnetic resonance spectros...

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Bibliographic Details
Published in:Journal of cardiovascular translational research 2010-08, Vol.3 (4), p.384-396
Main Authors: Obrzut, Sebastian, Jamshidi, Neema, Karimi, Afshin, Birgersdotter-Green, Ulrika, Hoh, Carl
Format: Article
Language:English
Subjects:
Biomedical Engineering and Bioengineering
Biomedicine
Cardiology
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - metabolism
Cardiovascular Diseases - diagnostic imaging
Cardiovascular Diseases - metabolism
Heart Failure - diagnostic imaging
Heart Failure - metabolism
Heart Transplantation - diagnostic imaging
Human Genetics
Humans
Hypertension - diagnostic imaging
Hypertension - metabolism
Magnetic Resonance Spectroscopy
Mathematical Computing
Medicine
Medicine & Public Health
Myocardial Ischemia - diagnostic imaging
Myocardial Ischemia - metabolism
Myocardium - metabolism
Myocardium - pathology
Positron-Emission Tomography
Radiopharmaceuticals - metabolism
Tomography, Emission-Computed, Single-Photon
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Summary:Current imaging methods have focused on evaluation of myocardial anatomy and function. However, since myocardial metabolism and function are interrelated, metabolic myocardial imaging techniques, such as positron emission tomography, single photon emission tomography, and magnetic resonance spectroscopy present novel opportunities for probing myocardial pathology and developing new therapeutic approaches. Potential clinical applications of metabolic imaging include hypertensive and ischemic heart disease, heart failure, cardiac transplantation, as well as cardiomyopathies. Furthermore, response to therapeutic intervention can be monitored using metabolic imaging. Analysis of metabolic data in the past has been limited, focusing primarily on isolated metabolites. Models of myocardial metabolism, however, such as the oxygen transport and cellular energetics model and constraint-based metabolic network modeling, offer opportunities for evaluation interactions between greater numbers of metabolites in the heart. In this review, the roles of metabolic myocardial imaging and analysis of metabolic data using modeling methods for expanding our understanding of cardiac pathology are discussed.
ISSN:1937-5387
1937-5395
DOI:10.1007/s12265-010-9170-1