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Imaging and Modeling of Myocardial Metabolism
Current imaging methods have focused on evaluation of myocardial anatomy and function. However, since myocardial metabolism and function are interrelated, metabolic myocardial imaging techniques, such as positron emission tomography, single photon emission tomography, and magnetic resonance spectros...
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| Published in: | Journal of cardiovascular translational research 2010-08, Vol.3 (4), p.384-396 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c441t-15d9a82c3b18091d3352682de2e4329d2c616e2187ef6f50ea6e7ad68c7d97e03 |
| container_end_page | 396 |
| container_issue | 4 |
| container_start_page | 384 |
| container_title | Journal of cardiovascular translational research |
| container_volume | 3 |
| creator | Obrzut, Sebastian Jamshidi, Neema Karimi, Afshin Birgersdotter-Green, Ulrika Hoh, Carl |
| description | Current imaging methods have focused on evaluation of myocardial anatomy and function. However, since myocardial metabolism and function are interrelated, metabolic myocardial imaging techniques, such as positron emission tomography, single photon emission tomography, and magnetic resonance spectroscopy present novel opportunities for probing myocardial pathology and developing new therapeutic approaches. Potential clinical applications of metabolic imaging include hypertensive and ischemic heart disease, heart failure, cardiac transplantation, as well as cardiomyopathies. Furthermore, response to therapeutic intervention can be monitored using metabolic imaging. Analysis of metabolic data in the past has been limited, focusing primarily on isolated metabolites. Models of myocardial metabolism, however, such as the oxygen transport and cellular energetics model and constraint-based metabolic network modeling, offer opportunities for evaluation interactions between greater numbers of metabolites in the heart. In this review, the roles of metabolic myocardial imaging and analysis of metabolic data using modeling methods for expanding our understanding of cardiac pathology are discussed. |
| doi_str_mv | 10.1007/s12265-010-9170-1 |
| format | article |
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Trans. Res</addtitle><addtitle>J Cardiovasc Transl Res</addtitle><description>Current imaging methods have focused on evaluation of myocardial anatomy and function. However, since myocardial metabolism and function are interrelated, metabolic myocardial imaging techniques, such as positron emission tomography, single photon emission tomography, and magnetic resonance spectroscopy present novel opportunities for probing myocardial pathology and developing new therapeutic approaches. Potential clinical applications of metabolic imaging include hypertensive and ischemic heart disease, heart failure, cardiac transplantation, as well as cardiomyopathies. Furthermore, response to therapeutic intervention can be monitored using metabolic imaging. Analysis of metabolic data in the past has been limited, focusing primarily on isolated metabolites. 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| identifier | ISSN: 1937-5387 |
| ispartof | Journal of cardiovascular translational research, 2010-08, Vol.3 (4), p.384-396 |
| issn | 1937-5387 1937-5395 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2899022 |
| source | Springer Nature |
| subjects | Biomedical Engineering and Bioengineering Biomedicine Cardiology Cardiomyopathies - diagnostic imaging Cardiomyopathies - metabolism Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - metabolism Heart Failure - diagnostic imaging Heart Failure - metabolism Heart Transplantation - diagnostic imaging Human Genetics Humans Hypertension - diagnostic imaging Hypertension - metabolism Magnetic Resonance Spectroscopy Mathematical Computing Medicine Medicine & Public Health Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - metabolism Myocardium - metabolism Myocardium - pathology Positron-Emission Tomography Radiopharmaceuticals - metabolism Tomography, Emission-Computed, Single-Photon |
| title | Imaging and Modeling of Myocardial Metabolism |
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