Reimplantation of the resected tumour-bearing segment after recycling using liquid nitrogen for osteosarcoma

Reconstruction after en block resection of malignant tumours is still the subject of debate. We questioned the effectiveness of reconstruction by reimplanting the tumour-bearing segment after recycling in liquid nitrogen. Ten patients with osteosarcoma around the knee were included, with a mean age...

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Bibliographic Details
Published in:International orthopaedics 2009-10, Vol.33 (5), p.1365-1370
Main Authors: Abdel Rahman, Mohamed, Bassiony, Ayman, Shalaby, Hisham
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - pathology
Bone Neoplasms - surgery
Bone Transplantation - methods
Female
Femur - pathology
Femur - surgery
Health Care Costs
Humans
Knee
Knee Prosthesis
Limb Salvage - economics
Limb Salvage - methods
Male
Medicine
Medicine & Public Health
Neoplasm Recurrence, Local
Nitrogen
Nitrogen - pharmacology
Original Paper
Orthopedics
Osseointegration
Osteosarcoma
Osteosarcoma - diagnostic imaging
Osteosarcoma - pathology
Osteosarcoma - surgery
Prospective Studies
Radiography
Reconstruction
Recovery of Function
Recycling
Replantation
Tibia - pathology
Tibia - surgery
Transplantation, Autologous
Treatment Outcome
Tumors
Young Adult
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Summary:Reconstruction after en block resection of malignant tumours is still the subject of debate. We questioned the effectiveness of reconstruction by reimplanting the tumour-bearing segment after recycling in liquid nitrogen. Ten patients with osteosarcoma around the knee were included, with a mean age of 21 years. The operative technique included wide en bloc excision, debridement, and management of the resected segment with liquid nitrogen followed by reimplantation and internal fixation. At a mean follow-up of 4.5 years there was no local or systemic recurrence and the mean functional score was 82.4%. The frozen graft united proximally and distally in all but one patient in a period ranging from six to ten months. The effectiveness of this reconstruction technique in properly selected patients with osteosarcoma is comparable to other techniques of biological reconstruction with the added benefit of being simple, cheap and durable.
ISSN:0341-2695
1432-5195
DOI:10.1007/s00264-009-0773-6