The use of recombinant human BMP-2 as a salvage procedure in the pediatric spine: a report on 3 cases

The study is a retrospective case series. The objective is to review the results after off-label recombinant human BMP-2 (rhBMP-2) use in the pediatric spine after previously failed spinal fusion. Non-union in the pediatric spine is a challenging condition associated with increased morbidity due to...

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Bibliographic Details
Published in:European spine journal 2010-07, Vol.19 (Suppl 2), p.135-139
Main Authors: Mladenov, Kiril V., Kunkel, Philip, Stuecker, Ralf
Format: Article
Language:English
Subjects:
Age Factors
Bone Morphogenetic Protein 2 - pharmacology
Bone Morphogenetic Protein 2 - therapeutic use
Bone Regeneration - drug effects
Bone Regeneration - physiology
Case Report
Child
Child, Preschool
Humans
Male
Medicine
Medicine & Public Health
Neurosurgery
Postoperative Complications - drug therapy
Postoperative Complications - etiology
Postoperative Complications - physiopathology
Recombinant Fusion Proteins - pharmacology
Recombinant Fusion Proteins - therapeutic use
Retrospective Studies
Spinal Fusion - adverse effects
Spine - growth & development
Spine - pathology
Spine - surgery
Surgical Orthopedics
Wound Healing - drug effects
Wound Healing - physiology
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Summary:The study is a retrospective case series. The objective is to review the results after off-label recombinant human BMP-2 (rhBMP-2) use in the pediatric spine after previously failed spinal fusion. Non-union in the pediatric spine is a challenging condition associated with increased morbidity due to instability, neurological impairment or multiple revision surgeries. BMP has been used with good results in the adult spine; however, information on its use in the pediatric population is still lacking. rhBMP-2 was used at our institution at revision posterior spinal surgery in three patients. Solid spinal fusion was achieved in all three cases despite underlying bone dysplasia (Hurler’s disease), instability or bony substance loss. No adverse reactions due to rhBMP-2 use were observed. rhBMP-2 should be considered as potential option to achieve spinal fusion in children with compromised bone healing due to congenital, local or systemic conditions.
ISSN:0940-6719
1432-0932
DOI:10.1007/s00586-009-1179-2