Snail: More than EMT

Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays important role in cell surviv...

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Bibliographic Details
Published in:Cell adhesion & migration 2010-04, Vol.4 (2), p.199-203
Main Authors: Wu, Yadi, Zhou, Binhua P.
Format: Article
Language:English
Subjects:
Animals
Apoptosis - genetics
Apoptosis - physiology
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Commentaries & Views
Cycle
Epithelial Cells - cytology
Epithelial Cells - metabolism
Humans
Landes
Mesoderm - cytology
Mesoderm - metabolism
Models, Biological
Neoplasms - genetics
Neoplasms - metabolism
Organogenesis
Proteins
Snail Family Transcription Factors
Transcription Factors - genetics
Transcription Factors - metabolism
Citations: Items that this one cites
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Summary:Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions of Snail in development and disease. Understanding the regulation and functional roles of Snail will shed new light on the mechanism of tumor progression and the development of novel cancer therapies.
ISSN:1933-6918
1933-6926
DOI:10.4161/cam.4.2.10943