Effect size of reference memory deficits in the Morris water maze in Tg2576 mice

The most widely used mouse model of Alzheimer's disease is the Tg2576 (APP SWE) model. While general agreement about their neuropathology prevails, disparate results concerning cognitive changes have been reported. To resolve this controversy, we combined Morris water maze data collected over &...

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Bibliographic Details
Published in:Behavioural brain research 2010-09, Vol.212 (1), p.115-120
Main Authors: Reed, Miranda N., Liu, Peng, Kotilinek, Linda A., Ashe, Karen H.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Age Factors
Alzheimer Disease - complications
Alzheimer Disease - genetics
Alzheimer's disease
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - metabolism
Analysis of Variance
Animals
Behavioral psychophysiology
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Disease Models, Animal
Effect size
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - genetics
Humans
Male
Maze Learning - physiology
Medical sciences
Memory Disorders - etiology
Memory Disorders - genetics
Mice
Mice, Transgenic
Morris water maze
Mutation - genetics
Neurology
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Sample size
Sex Factors
Tg2576
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Description
Summary:The most widely used mouse model of Alzheimer's disease is the Tg2576 (APP SWE) model. While general agreement about their neuropathology prevails, disparate results concerning cognitive changes have been reported. To resolve this controversy, we combined Morris water maze data collected over >10 years to determine the extent of memory impairment. APP SWE mice exhibited an age-dependent decline in memory, but the effect size was small when compared to non-transgenic littermates. Larger effect sizes were achieved when comparing APP SWE and Tg5469 (APP WT) mice.
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2010.03.037