Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes

Abstract The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either...

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Bibliographic Details
Published in:Vaccine 2010-07, Vol.28 (31), p.5017-5022
Main Authors: Penfound, Thomas A, Chiang, Edna Y, Ahmed, Elwaleed A, Dale, James B
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Bacterial - blood
Antigens, Bacterial - immunology
Applied microbiology
Bacterial Outer Membrane Proteins - immunology
Bacteriology
Biological and medical sciences
Carrier Proteins - immunology
Cross Protection
Epitopes
Epitopes - immunology
Experiments
Female
Fundamental and applied biological sciences. Psychology
Group A streptococci
Heptavalent Pneumococcal Conjugate Vaccine
Immunization
M protein
Methods
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Microbiology
Miscellaneous
Peptides
Pneumococcal Vaccines - immunology
Proteins
Rabbits
Serum Bactericidal Test
Streptococcal Infections - immunology
Streptococcal Infections - prevention & control
Streptococcus
Streptococcus pyogenes
Streptococcus pyogenes - immunology
Studies
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Summary:Abstract The amino terminal region of group A streptococcal M proteins evokes type-specific immunity while the conserved C-repeat epitopes evoke cross-protective immunity against multiple serotypes. The present studies were undertaken to compare the protective efficacy of vaccines containing either type-specific (hexavalent vaccine) or conserved C-repeat (J14 vaccine) M protein epitopes and to determine if combination vaccines resulted in enhanced levels of protection. Our results indicated that the protective efficacy of the type-specific vaccine was significantly greater than that of J14 and that the addition of J14 to vaccine formulations did not enhance the level of protection achieved with type-specific formulations.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2010.05.018