Multi-site study of HPV type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in England

Background: Knowledge of the prevalence of type-specific human papillomavirus (HPV) infections is necessary to predict the expected, and to monitor the actual, impact of HPV immunisation and to design effective screening strategies for vaccinated populations. Methods: Residual specimens of cervical...

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Bibliographic Details
Published in:British journal of cancer 2010-07, Vol.103 (2), p.209-216
Main Authors: Howell-Jones, R, Bailey, A, Beddows, S, Sargent, A, de Silva, N, Wilson, G, Anton, J, Nichols, T, Soldan, K, Kitchener, H
Format: Article
Language:English
Subjects:
631/326/596/2560
692/699/67/1517/1371
692/699/67/2322
692/700/565/251/1567
Adenocarcinoma - virology
Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Biopsy
Cancer Research
Cervical cancer
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - virology
Cervix Uteri - virology
Drug Resistance
England - epidemiology
Epidemiology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Human papillomavirus
Human papillomavirus 16 - isolation & purification
Human papillomavirus 18 - isolation & purification
Humans
Medical sciences
Middle Aged
Molecular Diagnostics
Molecular Medicine
Neoplasms, Squamous Cell - virology
Oncology
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Papillomavirus Vaccines
Prevalence
Tumors
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
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Summary:Background: Knowledge of the prevalence of type-specific human papillomavirus (HPV) infections is necessary to predict the expected, and to monitor the actual, impact of HPV immunisation and to design effective screening strategies for vaccinated populations. Methods: Residual specimens of cervical cytology ( N =4719), CIN3/CGIN and cervical cancer biopsies ( N =1515) were obtained from sites throughout England, anonymised and tested for HPV DNA using the Linear Array typing system (Roche). Results: The prevalence of HPV 16 and/or 18 (with or without another high-risk (HR) type) was 76% in squamous cell carcinomas, 82% in adeno/adenosquamous carcinomas and 63% and 91% in CIN3 and CGIN, respectively. Of all HR HPV-infected women undergoing cytology, non-vaccine HPV types only were found in over 60% of those with mild dyskaryosis or below, and in
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6605747