Primary small cell carcinoma of the breast with TTF-1 and neuroendocrine marker expressing carcinoma in situ

Primary small cell carcinoma (SmCC) of the breast is very rare and may be difficult to distinguish from metastatic small cell carcinoma. Confident histopathological diagnosis of a primary breast SmCC requires the demonstration of an in situ component. We report a case of primary small cell carcinoma...

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Bibliographic Details
Published in:International journal of clinical and experimental pathology 2010-06, Vol.3 (6), p.629-633
Main Authors: Christie, Michael, Chin-Lenn, Laura, Watts, Monique M, Tsui, Alpha E, Buchanan, Malcolm R
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carcinoma in Situ - metabolism
Carcinoma in Situ - pathology
Carcinoma, Small Cell - metabolism
Carcinoma, Small Cell - pathology
Case Report
Erythema Nodosum - complications
Fatal Outcome
Female
Humans
Immunohistochemistry
Middle Aged
Nuclear Proteins - biosynthesis
Pleural Effusion - complications
Positron-Emission Tomography
Thyroid Nuclear Factor 1
Tomography, X-Ray Computed
Transcription Factors - biosynthesis
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Summary:Primary small cell carcinoma (SmCC) of the breast is very rare and may be difficult to distinguish from metastatic small cell carcinoma. Confident histopathological diagnosis of a primary breast SmCC requires the demonstration of an in situ component. We report a case of primary small cell carcinoma of the breast with coexisting carcinoma in situ in which the invasive carcinoma and in situ component both expressed neuroendocrine markers and Thyroid transcription factor-1 (TTF-1) by immunohistochemistry. Expression of neuroendocrine markers and TTF-1 in the in situ component allowed a highly confident diagnosis of primary small cell carcinoma of the breast. To our knowledge there is only one previous report of TTF-1 expressing in situ carcinoma associated with a primary SmCC of the breast.
ISSN:1936-2625