Evidence of Bordetella pertussis infection in vaccinated 1-year-old Danish children

We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children...

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Bibliographic Details
Published in:European journal of pediatrics 2010-09, Vol.169 (9), p.1119-1122
Main Authors: von Linstow, Marie-Louise, Pontoppidan, Peter Lotko, von König, Carl-Heinz Wirsing, Cherry, James D., Hogh, Birthe
Format: Article
Language:English
Subjects:
Age
Antibodies
Antibodies, Bacterial - blood
Antigens
Bacterial diseases
Biological and medical sciences
Bordetella pertussis
Bordetella pertussis - immunology
Cohort Studies
Denmark
Disease
Ent and stomatologic bacterial diseases
Epidemiology
Female
General aspects
Hemagglutinins - immunology
Hospitals
Human bacterial diseases
Humans
Immunization
Immunoglobulin A - blood
Immunoglobulin G - blood
Infant
Infections
Infectious diseases
Male
Medical sciences
Medicine
Medicine & Public Health
Original Paper
Pediatrics
Pertussis Toxin - immunology
Pertussis Vaccine - administration & dosage
Pertussis Vaccine - immunology
Public health. Hygiene
Public health. Hygiene-occupational medicine
Vaccination - methods
Vaccines
Viral infections
Whooping cough
Whooping Cough - prevention & control
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Description
Summary:We measured IgA and IgG antibodies to pertussis toxin (PT) and filamentous hemagglutinin (FHA) in sera from 203 1-year-old children who had received one to three doses of a monocomponent PT toxoid vaccine. Ten children (5%) had IgA antibody to PT indicating recent infection; seven of these children had received three doses of vaccine. PT IgA responders did not have significantly longer coughing episodes than PT IgA non-responders. Since an IgA antibody response occurs in only ∼50% of infected children, the actual infection rate in our cohort is estimated to ∼10%. The apparent high Bordetella pertussis infection rate in Danish infants suggests that the monocomponent PT toxoid vaccine used in Denmark has limited efficacy against B. pertussis infection. A prospective immunization study comparing a multi-component vaccine with the present monocomponent PT toxoid vaccine should be undertaken.
ISSN:0340-6199
1432-1076
DOI:10.1007/s00431-010-1192-9