Occupational determinants of serum cholinesterase inhibition among organophosphate-exposed agricultural pesticide handlers in Washington State

ObjectiveTo identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides.MethodsWe conducted a longitudinal study among 154 agricultural pesticide handlers who participated i...

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Bibliographic Details
Published in:Occupational and environmental medicine (London, England) England), 2010-06, Vol.67 (6), p.375-386
Main Authors: Hofmann, Jonathan N, Keifer, Matthew C, De Roos, Anneclaire J, Fenske, Richard A, Furlong, Clement E, van Belle, Gerald, Checkoway, Harvey
Format: Article
Language:English
Subjects:
Adult
agricultural workers
Agricultural Workers' Diseases - blood
Agricultural Workers' Diseases - epidemiology
Agriculture
Agrochemicals
Algorithms
Aprons
Biological and medical sciences
Chemical hazards
Cholinesterase
Cholinesterase Inhibitors - blood
Cholinesterase Inhibitors - pharmacology
Cholinesterases
Cleaning
Farmworkers
Humans
Inhibition
Insecticides
Insecticides - toxicity
Longitudinal Studies
Male
Mechanical ventilators
Medical sciences
Middle Aged
Nitriles
Occupational exposure
Occupational Exposure - adverse effects
Organophosphates
Organophosphorus Compounds - toxicity
Pain
Personal protective equipment
Pesticides
Pesticides, fertilizers and other agrochemicals toxicology
Protective clothing
Protective equipment
Risk Assessment
Risk factors
Socioeconomic Factors
Toxicity
Toxicology
Washington
Workers
Workplace
Young Adult
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Summary:ObjectiveTo identify potential risk factors for serum cholinesterase (BuChE) inhibition among agricultural pesticide handlers exposed to organophosphate (OP) and N-methyl-carbamate (CB) insecticides.MethodsWe conducted a longitudinal study among 154 agricultural pesticide handlers who participated in the Washington State cholinesterase monitoring program in 2006 and 2007. BuChE inhibition was analysed in relation to reported exposures before and after adjustment for potential confounders using linear regression. ORs estimating the risk of BuChE depression (>20% from baseline) were also calculated for selected exposures based on unconditional logistic regression analyses.ResultsAn overall decrease in mean BuChE activity was observed among study participants at the time of follow-up testing during the OP/CB spray season relative to pre-season baseline levels (mean decrease of 5.6%, p
ISSN:1351-0711
1470-7926
DOI:10.1136/oem.2009.046391