Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline

Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detectable even while ingesting a normal choline-adequate...

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Bibliographic Details
Published in:The FASEB journal 2010-08, Vol.24 (8), p.2962-2975
Main Authors: Sha, Wei, da Costa, Kerry-Ann, Fischer, Leslie M, Milburn, Michael V, Lawton, Kay A, Berger, Alvin, Jia, Wei, Zeisel, Steven H
Format: Article
Language:English
Subjects:
Choline - administration & dosage
Choline Deficiency - complications
Diet
Fats - analysis
fatty liver
Humans
Liver - chemistry
Liver Diseases - etiology
metabolomics
Metabolomics - methods
PEMT
plasma
Predictive Value of Tests
Research Communications
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Summary:Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detectable even while ingesting a normal choline-adequate diet. We determined whether metabolomic profiling of plasma at baseline could predict whether humans will develop liver dysfunction when deprived of dietary choline. Fifty-three participants were fed a diet containing 550 mg choline/70 kg/d for 10 d and then fed
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.09-154054