Serum Persistent Organic Pollutants and Duration of Lactation among Mexican-American Women

Background. Research suggests that estrogenic endocrine-disrupting chemicals interfere with lactation. Objectives. (1) to determine if estrogenic persistent organic pollutants (POPs) are associated with shortened lactation duration; (2) to determine whether previous breastfeeding history biases asso...

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Bibliographic Details
Published in:Journal of Environmental and Public Health 2010-01, Vol.2010 (2010), p.141-151
Main Authors: Weldon, Rosana H., Webster, Monique, Harley, Kim G., Bradman, Asa, Fenster, Laura, Davis, Mark D., Hubbard, Alan, Barr, Dana B., Holland, Nina, Eskenazi, Brenda
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bias
Breastfeeding & lactation
California
Endocrine disruptors
Endocrine Disruptors - blood
Endocrine Disruptors - toxicity
Estrogens - blood
Estrogens - toxicity
Female
Humans
Hydrocarbons, Chlorinated - blood
Hydrocarbons, Chlorinated - toxicity
Kaplan-Meier Estimate
Lactation - blood
Lactation - drug effects
Lactation - ethnology
Longitudinal Studies
Medical research
Mexican Americans
Middle Aged
PCB
Pesticides - blood
Pesticides - toxicity
Polychlorinated biphenyls
Polychlorinated Biphenyls - blood
Polychlorinated Biphenyls - toxicity
Pregnancy
Principal Component Analysis
Proportional Hazards Models
Self Report
Time Factors
Womens health
Young Adult
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Summary:Background. Research suggests that estrogenic endocrine-disrupting chemicals interfere with lactation. Objectives. (1) to determine if estrogenic persistent organic pollutants (POPs) are associated with shortened lactation duration; (2) to determine whether previous breastfeeding history biases associations. Methods and Results. We measured selected organochlorines and polychlorinated biphenyls (p,p′-DDE, p,p′-DDT, o,p′-DDT, β-hexachlorocyclohexane, hexachlorobenzene, and PCBs 44, 49, 52, 118, 138, 153, and 180) in serum from 366 low-income, Mexican-American pregnant women living in an agricultural region of California and assessed breastfeeding duration by questionnaires. We found no association between DDE, DDT, or estrogenic POPs with shortened lactation duration, but rather associations for two potentially estrogenic POPs with lengthened lactation duration arose (HR [95% CI]: 0.6 [0.4, 0.8] for p,p′-DDE & 0.8 [0.6, 1.0] for PCB 52). Associations between antiestrogenic POPs (PCBs 138 and 180) and shortened lactation duration were attributed to a lactation history bias. Conclusion. Estrogenic POPs were not associated with shortened lactation duration, but may be associated with longer lactation duration.
ISSN:1687-9805
1687-9813
DOI:10.1155/2010/861757