Comparing the Effectiveness of Malaria Vector-Control Interventions Through a Mathematical Model

Although some malaria-control programs are beginning to combine insecticide-treated nets (ITNs) and indoor residual spraying (IRS), little is known about the effectiveness of such combinations. We use a mathematical model to compare the effectiveness of ITNs and IRS with dichlorodiphenyltrichloroeth...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2010-08, Vol.83 (2), p.230-240
Main Authors: CHITNIS, Nakul, SCHAPIRA, Allan, SMITH, Thomas, STEKETEE, Richard
Format: Article
Language:English
Subjects:
Aerosols
Animals
Biological and medical sciences
Computer Simulation
DDT
Human protozoal diseases
Infectious diseases
Insecticides
Malaria
Malaria - prevention & control
Medical sciences
Models, Biological
Mosquito Control - methods
Mosquito Nets
Parasitic diseases
Phenylcarbamates
Protozoal diseases
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although some malaria-control programs are beginning to combine insecticide-treated nets (ITNs) and indoor residual spraying (IRS), little is known about the effectiveness of such combinations. We use a mathematical model to compare the effectiveness of ITNs and IRS with dichlorodiphenyltrichloroethane (DDT) or bendiocarb, applied singly and in combination, in an epidemiological setting based in Namawala, Tanzania, with Anopheles gambiae as the primary vector. Our model indicates that although both IRS (with DDT) and ITNs provide personal protection, humans with only ITNs are better protected than those with only IRS, and suggests that high coverage of IRS with bendiocarb may interrupt transmission, as can simultaneous high coverage of ITNs and IRS with DDT. When adding a second vector-control intervention, it is more effective to cover the unprotected population first. Although our model includes some assumptions and approximations that remain to be addressed, these findings should be useful for prioritizing and designing future field research.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2010.09-0179