Cartilage repair: A review of Stanmore experience in the treatment of osteochondral defects in the knee with various surgical techniques

Articular cartilage damage in the young adult knee, if left untreated, it may proceed to degenerative osteoarthritis and is a serious cause of disability and loss of function. Surgical cartilage repair of an osteochondral defect can give the patient significant relief from symptoms and preserve the...

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Bibliographic Details
Published in:Indian journal of orthopaedics 2010-07, Vol.44 (3), p.238-245
Main Authors: Vijayan, S., Bentley, G., Briggs, T. W. R., Skinner, J. A., Carrington, R. W. J., Pollock, R., Flanagan, A. M.
Format: Article
Language:English
Subjects:
Care and treatment
Cartilage
Conservative Orthopedics
Gene therapy
Injuries
Joint surgery
Knee
Medicine & Public Health
Methods
Orthopedic surgery
Orthopedics
Osteoarthritis
Review
Review Article
Studies
Surgical Orthopedics
Trauma
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Description
Summary:Articular cartilage damage in the young adult knee, if left untreated, it may proceed to degenerative osteoarthritis and is a serious cause of disability and loss of function. Surgical cartilage repair of an osteochondral defect can give the patient significant relief from symptoms and preserve the functional life of the joint. Several techniques including bone marrow stimulation, cartilage tissue based therapy, cartilage cell seeded therapies and osteotomies have been described in the literature with varying results. Established techniques rely mainly on the formation of fibro-cartilage, which has been shown to degenerate overtime due to shear forces. The implantation of autologous cultured chondrocytes into an osteochondral defect, may replace damaged cartilage with hyaline or hyaline-like cartilage. This clinical review assesses current surgical techniques and makes recommendations on the most appropriate method of cartilage repair when managing symptomatic osteochondral defects of the knee. We also discuss the experience with the technique of autologous chondrocyte implantation at our institution over the past 11 years.
ISSN:0019-5413
1998-3727
DOI:10.4103/0019-5413.65136