Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder

Abstract Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between t...

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Bibliographic Details
Published in:Psychiatry research. Neuroimaging 2010-06, Vol.182 (3), p.207-210
Main Authors: Chepenik, Lara G, Raffo, Mariella, Hampson, Michelle, Lacadie, Cheryl, Wang, Fei, Jones, Monique M, Pittman, Brian, Skudlarski, Pawel, Blumberg, Hilary P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Amygdala
Amygdala - blood supply
Amygdala - physiopathology
Bipolar disorder
Bipolar Disorder - pathology
Bipolar Disorder - physiopathology
Brain Mapping
Female
FMRI
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neural Pathways - blood supply
Neural Pathways - physiopathology
Oxygen - blood
Prefrontal cortex
Prefrontal Cortex - blood supply
Prefrontal Cortex - physiopathology
Psychiatry
Radiology
Rest - physiology
Young Adult
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Summary:Abstract Trait abnormalities in bipolar disorder (BD) within the ventral prefrontal cortex (vPFC) and the amygdala suggest dysfunction in their connectivity. This study employed low frequency resting state functional magnetic resonance imaging (LFRS-fMRI) to analyze functional connectivity between the vPFC and the amygdala in BD. LFRS-fMRI identified a negative correlation in vPFC–amygdala activity, and the magnitude of this correlation was greater in healthy participants than in subjects with BD. Additionally, whole-brain analysis revealed higher correlations between left and right vPFC in BD, as well as with ventral striatum.
ISSN:0925-4927
1872-7506
DOI:10.1016/j.pscychresns.2010.04.002