Adaptive Resistance to the “Last Hope” Antibiotics Polymyxin B and Colistin in Pseudomonas aeruginosa Is Mediated by the Novel Two-Component Regulatory System ParR-ParS

• Published in: Antimicrobial Agents and Chemotherapy 2010-08, Vol.54 (8), p.3372-3382
• Main Authors: FERNANDEZ, Lucía, GOODERHAM, W. James, BAINS, Manjeet, MCPHEE, Joseph B, WIEGAND, Irith, HANCOCK, Robert E. W
• Format: Article
• Language: English
• Subjects: Adaptation, Physiological; Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological and medical sciences; Colistin; Colistin - pharmacology; Drug Resistance, Bacterial; Drug Resistance, Bacterial - genetics; Gene Expression Regulation, Bacterial; Humans; Mechanisms of Resistance; Medical sciences; Microbial Sensitivity Tests; Mutation; Pharmacology. Drug treatments; Polymyxin B; Polymyxin B - pharmacology; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - genetics; Repressor Proteins - genetics; Repressor Proteins - metabolism; Salmonella; Signal Transduction
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.00242-10

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