Intrathoracic Endotracheal Metastasis from Nasopharyngeal Carcinoma:A First Case Report and Review of the Literature

Intrathoracic endotracheal metastasis from a very distant site is extremely rare. We report the first case of such a disease in a 68-year-old man with nasopharyngeal carcinoma who presented with a cough and hemoptysis 34 months after finishing radiotherapy. Prior to tracheal metastasis, he developed...

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Bibliographic Details
Published in:Case reports in oncology 2010-05, Vol.3 (2), p.160-164
Main Authors: Lu, Heming, Chen, Jiaxin, Xie, Yanyan, Cheng, Jinjian, Hao, Yanrong, Peng, Luxing, Pang, Qiang, Deng, Shan, Gu, Junzhao, Qin, Jian, Lu, Zhiping
Format: Article
Language:English
Subjects:
Endotracheal malignancy
Metastatic disease
Nasopharyngeal carcinoma
Published: May 2010
Radiotherapy
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Summary:Intrathoracic endotracheal metastasis from a very distant site is extremely rare. We report the first case of such a disease in a 68-year-old man with nasopharyngeal carcinoma who presented with a cough and hemoptysis 34 months after finishing radiotherapy. Prior to tracheal metastasis, he developed a solitary metastasis in the lung and underwent chemotherapy followed by radiotherapy. Computed tomography showed the presence of an enlarged lymph node in the para-aortic arch. Fiberoptic bronchoscopy revealed an endotracheal tumor 1 cm above the carina. Histological and immunohistochemical analyses confirmed its nasopharyngeal origin. He was treated with conventional radiotherapy and three-dimensional conformal radiotherapy; complete tumor remission was achieved. He died of nonmalignant disease with no signs of tumor recurrence 2 years after treatment completion. Radiotherapy may be an appropriate management approach to achieve long-term tumor control for this disease.
ISSN:1662-6575
1662-6575
DOI:10.1159/000314233