Lateral fast muscle fibers originate from the posterior lip of the teleost dermomyotome

The predominant source of myogenic cells in vertebrates is the dermomyotome (DM). In teleost fish, recent research has provided a useful but limited picture of how myogenic precursors originate from the DM and how they develop into muscle fibers. Here, we combine detailed morphological analysis with...

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Bibliographic Details
Published in:Developmental dynamics 2008-11, Vol.237 (11), p.3233-3239
Main Authors: Steinbacher, P., Stadlmayr, V., Marschallinger, J., Sänger, A.M., Stoiber, W.
Format: Article
Language:English
Subjects:
Amniota
Animals
Biological Evolution
cell migration
Cell Movement - physiology
Epithelial Cells - cytology
Epithelial Cells - metabolism
fish muscle
Lip - cytology
Lip - embryology
MEF2
Muscle Development - physiology
Muscle Fibers, Fast-Twitch - cytology
Muscle Fibers, Fast-Twitch - metabolism
muscle growth
myogenesis
Myogenin
myotome
Pax7
Somites - cytology
Somites - embryology
Teleostei
Trout - embryology
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Summary:The predominant source of myogenic cells in vertebrates is the dermomyotome (DM). In teleost fish, recent research has provided a useful but limited picture of how myogenic precursors originate from the DM and how they develop into muscle fibers. Here, we combine detailed morphological analysis with examination of molecular markers in trout to describe the cellular mechanisms by which the lateral fast muscle growth zone is created during second phase myogenesis. Results suggest that this occurs by lateral‐to‐medial immigration of myogenic cells de‐epithelializing from the posterior DM lip. These cells then appear to stop proliferation and migrate anteriorly to finally differentiate into muscle fibres. This seems to be a continuation of the rotational cell movement that creates the teleost DM during early somite development. These findings suggest an evolutionary conserved role of the posterior DM lip in amniotes and fish. Developmental Dynamics 237:3233–3239, 2008. © 2008 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.21745