Loading…

Stress resistance and aging: Influence of genes and nutrition

Previous studies have shown that dermal fibroblast cell lines derived from young adult mice of the long-lived Snell dwarf ( d w / d w ), Ames dwarf ( df/ df) and growth hormone receptor knockout (GHR-KO) mouse stocks are resistant, in vitro, to the cytotoxic effects of hydrogen peroxide, cadmium, ul...

Full description

Saved in:
Bibliographic Details
Published in:Mechanisms of ageing and development 2006-08, Vol.127 (8), p.687-694
Main Authors: Harper, James M., Salmon, Adam B., Chang, Yayi, Bonkowski, Michael, Bartke, Andrzej, Miller, Richard A.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Previous studies have shown that dermal fibroblast cell lines derived from young adult mice of the long-lived Snell dwarf ( d w / d w ), Ames dwarf ( df/ df) and growth hormone receptor knockout (GHR-KO) mouse stocks are resistant, in vitro, to the cytotoxic effects of hydrogen peroxide, cadmium, ultraviolet light, paraquat, and heat. Here we show that, in contrast, fibroblasts from mice on low-calorie (CR) or low methionine (Meth-R) diets are not stress resistant in culture, despite the longevity induced by both dietary regimes. A second approach, involving induction of liver cell death in live animals using acetaminophen (APAP), documented hepatotoxin resistance in the CR and Meth-R mice, but d w / d w and GHR-KO mutant mice were not resistant to this agent, and were in fact more susceptible than littermate controls to the toxic effects of APAP. These data thus suggest that while resistance to stress is a common characteristic of experimental life span extension in mice, the cell types showing resistance may differ among the various models of delayed or decelerated aging.
ISSN:0047-6374
1872-6216
DOI:10.1016/j.mad.2006.04.002