Foveal Fine Structure in Retinopathy of Prematurity: An Adaptive Optics Fourier Domain Optical Coherence Tomography Study

• Published in: Investigative ophthalmology & visual science 2008-05, Vol.49 (5), p.2061-2070
• Main Authors: Hammer, Daniel X, Iftimia, Nicusor V, Ferguson, R. Daniel, Bigelow, Chad E, Ustun, Teoman E, Barnaby, Amber M, Fulton, Anne B
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Biological and medical sciences; Eye and associated structures. Visual pathways and centers. Vision; Fourier Analysis; Fovea Centralis - pathology; Fundamental and applied biological sciences. Psychology; Gestational Age; Humans; Infant, Low Birth Weight; Infant, Newborn; Medical sciences; Ophthalmology; Refraction, Ocular; Retinal Vessels - pathology; Retinopathies; Retinopathy of Prematurity - diagnosis; Tomography, Optical Coherence - methods; Vertebrates: nervous system and sense organs; Visual Acuity
• ISSN: 0146-0404; 1552-5783; 1552-5783
• DOI: 10.1167/iovs.07-1228

To describe the fine structure of the fovea in subjects with a history of mild retinopathy of prematurity (ROP) using adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT). High-speed, high-resolution AO-FDOCT videos were recorded in subjects with a history of ROP (n = 5; age range, 14-26 years) and in control subjects (n = 5; age range, 18-25 years). Custom software was used to extract foveal pit depth and volume from three-dimensional (3-D) retinal maps. The thickness of retinal layers as a function of retinal eccentricity was measured manually. The retinal vasculature in the parafoveal region was assessed. The foveal pit was wider and shallower in ROP than in control subjects. Mean pit depth, defined from the base to the level at which the pit reaches a lateral radius of 728 microm, was 121 microm compared with 53 microm. Intact, contiguous inner retinal layers overlay the fovea in ROP subjects but were absent in the control subjects. Mean full retinal thickness at the fovea was greater in the subjects with ROP (279.0 microm vs. 190.2 microm). The photoreceptor layer thickness did not differ between ROP and control subjects. An avascular zone was not identified in the subjects with ROP but was present in all the control subjects. The foveas of subjects with a history of mild ROP have significant structural abnormalities that are probably a consequence of perturbations of neurovascular development.