C. elegans RNAi space experiment (CERISE) in Japanese Experiment Module KIBO

We have started a space experiment using an experimental organism, the nematode Caenorhabditis elegans, in the Japanese Experiment Module, KIBO, of the International Space Station (ISS). The specimens were boarded by space shuttle Atlantis on mission STS-129 which launched from NASA Kennedy Space Ce...

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Bibliographic Details
Published in:Biological Sciences in Space 2009, Vol.23(4), pp.183-187
Main Authors: Higashitani, Atsushi, Hashizume, Toko, Sugimoto, Tomoko, Mori, Chihiro, Nemoto, Kanako, Etheridge, Timothy, Higashitani, Nahoko, Takanami, Takako, Suzuki, Hiromi, Fukui, Keiji, Yamazaki, Takashi, Ishioka, Noriaki, Szewczyk, Nathaniel, Higashibata, Akira
Format: Article
Language:English
Subjects:
Caenorhabditis elegans
Genomes
Muscles
Nematoda
Post-translation
RNA-mediated interference
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Summary:We have started a space experiment using an experimental organism, the nematode Caenorhabditis elegans, in the Japanese Experiment Module, KIBO, of the International Space Station (ISS). The specimens were boarded by space shuttle Atlantis on mission STS-129 which launched from NASA Kennedy Space Center on November 16, 2009. The purpose of the experiment was several-fold: (i) to verify the efficacy of RNA interference (RNAi) in space, (ii) to monitor transcriptional and post-translational alterations in the entire genome in space, and (iii) to investigate mechanisms regulating and countermeasures for muscle alterations in response to the space environment. In particular, this will be the first study to utilize RNAi in space.
ISSN:0914-9201
1349-967X
1349-967X
DOI:10.2187/bss.23.183