Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis

Integrin‐ and cadherin‐mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force‐mediated modulation of thei...

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Bibliographic Details
Published in:The EMBO journal 2010-08, Vol.29 (16), p.2753-2768
Main Authors: Papusheva, Ekaterina, Heisenberg, Carl-Philipp
Format: Article
Language:English
Subjects:
Adhesion
Animals
Binding sites
Cell Adhesion
Cell adhesion & migration
Cell Movement
EMBO37
Focus Review
Humans
Mechanotransduction, Cellular
Molecular biology
Morphology
Organogenesis
Signal transduction
spatial organization
tissue morphogenesis
Tissues
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Summary:Integrin‐ and cadherin‐mediated adhesion is central for cell and tissue morphogenesis, allowing cells and tissues to change shape without loosing integrity. Studies predominantly in cell culture showed that mechanosensation through adhesion structures is achieved by force‐mediated modulation of their molecular composition. The specific molecular composition of adhesion sites in turn determines their signalling activity and dynamic reorganization. Here, we will review how adhesion sites respond to mecanical stimuli, and how spatially and temporally regulated signalling from different adhesion sites controls cell migration and tissue morphogenesis. The Heisenberg laboratory reviews the spatial organization of signalling complexes at cell–matrix and cell–cell contact sites and its impact on cell integrity, cellular polarity and tissue morphogenesis.
ISSN:0261-4189
1460-2075
DOI:10.1038/emboj.2010.182