Synergistic protection by S-adenosylmethionine with vitamins C and E on liver injury induced by thioacetamide in rats

Free radicals are involved in the pathogenesis of acute liver injury induced by thioacetamide (TAA). We investigated the effects of S-adenosylmethionine (SAMe) combined with/without vitamins C and E on TAA-induced acute liver injury in rats. TAA was given intraperitoneally (200 mg kg −1). Antioxidan...

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Published in:Free radical biology & medicine 2006-02, Vol.40 (4), p.617-624
Main Authors: Ming, Zhi, Fan, Yi-jun, Yang, Xi, Wayne Lautt, W.
Format: Article
Language:English
Subjects:
Animals
Antioxidant
Antioxidants - therapeutic use
Ascorbic Acid - therapeutic use
Drug Combinations
Drug Synergism
Free radical
GSH
HISS
Insulin Resistance
Liver
Liver - drug effects
Liver - injuries
Male
Oxidative stress
Rats
Rats, Sprague-Dawley
S-Adenosylmethionine
S-Adenosylmethionine - therapeutic use
Thioacetamide
Thioacetamide - toxicity
Vitamin C
Vitamin E
Vitamin E - therapeutic use
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Summary:Free radicals are involved in the pathogenesis of acute liver injury induced by thioacetamide (TAA). We investigated the effects of S-adenosylmethionine (SAMe) combined with/without vitamins C and E on TAA-induced acute liver injury in rats. TAA was given intraperitoneally (200 mg kg −1). Antioxidant treatments (SAMe, 25 mg kg −1; vitamin C, 100 mg kg −1; vitamin E, 200 mg kg −1, intraperitoneal) were given 1 h later. Liver histology, enzymology, and ability to release hepatic insulin-sensitizing substance (HISS) were assessed. TAA caused liver tissue injury, increased liver enzymes, and decreased insulin sensitivity ( p 
ISSN:0891-5849
1873-4596
DOI:10.1016/j.freeradbiomed.2005.09.034