Increased cytochrome c correlates with poor survival in aggressive lymphoma

Mitochondria are central to a variety of cellular processes, from metabolism to cell death. In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma. Increased cytochrome c expr...

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Bibliographic Details
Published in:Oncology letters 2010-03, Vol.1 (2), p.227-230
Main Authors: WILKINSON, SARAH T, JOHNSON, DAVID B.F, TARDIF, HEATHER L, TOME, MARGARET E, BRIEHL, MARGARET M
Format: Article
Language:English
Subjects:
cytochrome c
diffuse large B-cell lymphoma
follicular lymphoma
gene expression profiling
mantle-cell lymphoma
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Summary:Mitochondria are central to a variety of cellular processes, from metabolism to cell death. In this study, we demonstrated that an increase in the critical mitochondrial protein, cytochrome c, correlated with drug resistance in a cell culture model of aggressive lymphoma. Increased cytochrome c expression was also correlated with decreased survival in the aggressive diffuse large B-cell and mantle cell lymphomas, but not in the indolent follicular lymphoma. This suggests that an increased reliance on the mitochondria for energy allows tumor cells to be metabolic opportunists and contribute to tumor development and drug resistance.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol_00000040