Iron and Porphyrin Trafficking in Heme Biogenesis

Iron is an essential element for diverse biological functions. In mammals, the majority of iron is enclosed within a single prosthetic group: heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria. However, iron is acquired from the environment...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 2010-08, Vol.285 (35), p.26753-26759
Main Authors: Schultz, Iman J., Chen, Caiyong, Paw, Barry H., Hamza, Iqbal
Format: Article
Language:English
Subjects:
Animals
Biological Transport - physiology
Cell Metabolism
Heme
Heme - biosynthesis
Humans
Iron - metabolism
Metabolism
Minireviews
Mitochondria - metabolism
Porphyrins - metabolism
Trafficking
Transport Metals
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Iron is an essential element for diverse biological functions. In mammals, the majority of iron is enclosed within a single prosthetic group: heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria. However, iron is acquired from the environment and subsequently assimilated into various cellular pathways, including heme synthesis. Both iron and heme are toxic but essential cofactors. How is iron transported from the extracellular milieu to the mitochondria? How are heme and heme intermediates coordinated with iron transport? Although recent studies have answered some questions, several pieces of this intriguing puzzle remain unsolved.
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.R110.119503