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Severe depression following á-interferon usage in a patient with chronic myeloid leukemia
Background: Chronic myeloid leukaemia (CML), with a median age of 40 years, is one of the commonest haematological malignancies in Nigeria. Cytoreductive agents, which were hitherto the mainstay of treatment, neither induce cytogenetic nor haematologic remission. Alpha-interferon (á-IFN), an endogen...
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| Published in: | African health sciences 2009-03, Vol.9 (1), p.54-56 |
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| container_title | African health sciences |
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| creator | Mamman, Aisha I Yusuf, A.J Aminu, Sm Sheikh, T.L Hassan, Dr A |
| description | Background: Chronic myeloid leukaemia (CML), with a median age of 40
years, is one of the commonest haematological malignancies in Nigeria.
Cytoreductive agents, which were hitherto the mainstay of treatment,
neither induce cytogenetic nor haematologic remission. Alpha-interferon
(á-IFN), an endogenous glycoprotein with cytotoxic and natural
killer cell enhancer effects has been found to induce haematologic and
cytogenetic remission in patients with CML, but neuro- psychiatric
complications of á -interferon (á-IFN) usage were not
reported in Nigeria. Objective: To report a case of deliberate
self-harm in University Lecturer as a side effect of á-IFN in the
treatment of CML Method: Clinical and laboratory follow up of a
patient receiving á-IFN in the management of CML from the time of
diagnosis of CML to the point of loss of contact. Result: Severe
depression is a complication that may adversely influence the clinical
outcome of á-IFN usage Conclusions/Recommendations: Although
interferon related depression is uncommon, it is suggested that
pre-therapy interferon assays and neuro-psychiatric assessment are
carried out in prospective users of á-IFN |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2932513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>746305640</sourcerecordid><originalsourceid>FETCH-LOGICAL-b364t-1fe92a2546072a4f92ef23ee57e4afba29775287f577ae82bdc6abd70a2a2dd3</originalsourceid><addsrcrecordid>eNpdkMtKxTAQhosoXo6-ggRcuKqkaS7tRhDxBoILz8pNmLbTc6JpckxaDz6Oz-KLGfCCCgMzzHzz889sZLuFYnVOBS03Uy0rmsuaip1sL8ZHSpks6mI722G04oxxvps93OMLBiQdrgLGaLwjvbfWr41bkPe33LgRQ48h9acICyTGESArGA26kazNuCTtMk1NS4ZXtN50xOL0hIOB_WyrBxvx4CvPsvnlxfz8Or-9u7o5P7vNm1LyMS96rBkwwSVVDHhfM-xZiSgUcugbYLVSglWqF0oBVqzpWglNpyikra4rZ9npp-xqagbs2uQrgNWrYAYIr9qD0X8nziz1wr9oVpdMFGUSOP4SCP55wjjqwcQWrQWHfopacVlSITlN5NE_8tFPwaXjNBOVVJVIH0_U4W9DP06-n56Ak0-gMd4ahz9EGwzo7-YypqA1LWj5ATy7kqY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2586785168</pqid></control><display><type>article</type><title>Severe depression following á-interferon usage in a patient with chronic myeloid leukemia</title><source>Open Access: PubMed Central</source><creator>Mamman, Aisha I ; Yusuf, A.J ; Aminu, Sm ; Sheikh, T.L ; Hassan, Dr A</creator><creatorcontrib>Mamman, Aisha I ; Yusuf, A.J ; Aminu, Sm ; Sheikh, T.L ; Hassan, Dr A</creatorcontrib><description>Background: Chronic myeloid leukaemia (CML), with a median age of 40
years, is one of the commonest haematological malignancies in Nigeria.
Cytoreductive agents, which were hitherto the mainstay of treatment,
neither induce cytogenetic nor haematologic remission. Alpha-interferon
(á-IFN), an endogenous glycoprotein with cytotoxic and natural
killer cell enhancer effects has been found to induce haematologic and
cytogenetic remission in patients with CML, but neuro- psychiatric
complications of á -interferon (á-IFN) usage were not
reported in Nigeria. Objective: To report a case of deliberate
self-harm in University Lecturer as a side effect of á-IFN in the
treatment of CML Method: Clinical and laboratory follow up of a
patient receiving á-IFN in the management of CML from the time of
diagnosis of CML to the point of loss of contact. Result: Severe
depression is a complication that may adversely influence the clinical
outcome of á-IFN usage Conclusions/Recommendations: Although
interferon related depression is uncommon, it is suggested that
pre-therapy interferon assays and neuro-psychiatric assessment are
carried out in prospective users of á-IFN</description><identifier>ISSN: 1680-6905</identifier><identifier>EISSN: 1729-0503</identifier><identifier>PMID: 20842244</identifier><language>eng</language><publisher>Uganda: Makerere University Medical School</publisher><subject>Adult ; Antiviral Agents - adverse effects ; Chronic myeloid leukaemia, interferon-á, depression ; Depression - chemically induced ; Depression - complications ; Depression - psychology ; Health and Medicine ; Humans ; Interferon-alpha - adverse effects ; Leukemia ; Leukemia, Myeloid, Chronic-Phase - diagnosis ; Leukemia, Myeloid, Chronic-Phase - drug therapy ; Male ; Medical treatment ; Mental disorders ; Pharmaceuticals ; Psychology ; Treatment Outcome</subject><ispartof>African health sciences, 2009-03, Vol.9 (1), p.54-56</ispartof><rights>Copyright 2009 - Makerere Medical School, Uganda</rights><rights>Copyright © Makerere Medical School, Uganda 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932513/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932513/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20842244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mamman, Aisha I</creatorcontrib><creatorcontrib>Yusuf, A.J</creatorcontrib><creatorcontrib>Aminu, Sm</creatorcontrib><creatorcontrib>Sheikh, T.L</creatorcontrib><creatorcontrib>Hassan, Dr A</creatorcontrib><title>Severe depression following á-interferon usage in a patient with chronic myeloid leukemia</title><title>African health sciences</title><addtitle>Afr Health Sci</addtitle><description>Background: Chronic myeloid leukaemia (CML), with a median age of 40
years, is one of the commonest haematological malignancies in Nigeria.
Cytoreductive agents, which were hitherto the mainstay of treatment,
neither induce cytogenetic nor haematologic remission. Alpha-interferon
(á-IFN), an endogenous glycoprotein with cytotoxic and natural
killer cell enhancer effects has been found to induce haematologic and
cytogenetic remission in patients with CML, but neuro- psychiatric
complications of á -interferon (á-IFN) usage were not
reported in Nigeria. Objective: To report a case of deliberate
self-harm in University Lecturer as a side effect of á-IFN in the
treatment of CML Method: Clinical and laboratory follow up of a
patient receiving á-IFN in the management of CML from the time of
diagnosis of CML to the point of loss of contact. Result: Severe
depression is a complication that may adversely influence the clinical
outcome of á-IFN usage Conclusions/Recommendations: Although
interferon related depression is uncommon, it is suggested that
pre-therapy interferon assays and neuro-psychiatric assessment are
carried out in prospective users of á-IFN</description><subject>Adult</subject><subject>Antiviral Agents - adverse effects</subject><subject>Chronic myeloid leukaemia, interferon-á, depression</subject><subject>Depression - chemically induced</subject><subject>Depression - complications</subject><subject>Depression - psychology</subject><subject>Health and Medicine</subject><subject>Humans</subject><subject>Interferon-alpha - adverse effects</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Chronic-Phase - diagnosis</subject><subject>Leukemia, Myeloid, Chronic-Phase - drug therapy</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Mental disorders</subject><subject>Pharmaceuticals</subject><subject>Psychology</subject><subject>Treatment Outcome</subject><issn>1680-6905</issn><issn>1729-0503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpdkMtKxTAQhosoXo6-ggRcuKqkaS7tRhDxBoILz8pNmLbTc6JpckxaDz6Oz-KLGfCCCgMzzHzz889sZLuFYnVOBS03Uy0rmsuaip1sL8ZHSpks6mI722G04oxxvps93OMLBiQdrgLGaLwjvbfWr41bkPe33LgRQ48h9acICyTGESArGA26kazNuCTtMk1NS4ZXtN50xOL0hIOB_WyrBxvx4CvPsvnlxfz8Or-9u7o5P7vNm1LyMS96rBkwwSVVDHhfM-xZiSgUcugbYLVSglWqF0oBVqzpWglNpyikra4rZ9npp-xqagbs2uQrgNWrYAYIr9qD0X8nziz1wr9oVpdMFGUSOP4SCP55wjjqwcQWrQWHfopacVlSITlN5NE_8tFPwaXjNBOVVJVIH0_U4W9DP06-n56Ak0-gMd4ahz9EGwzo7-YypqA1LWj5ATy7kqY</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Mamman, Aisha I</creator><creator>Yusuf, A.J</creator><creator>Aminu, Sm</creator><creator>Sheikh, T.L</creator><creator>Hassan, Dr A</creator><general>Makerere University Medical School</general><general>Makerere Medical School</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>200903</creationdate><title>Severe depression following á-interferon usage in a patient with chronic myeloid leukemia</title><author>Mamman, Aisha I ; Yusuf, A.J ; Aminu, Sm ; Sheikh, T.L ; Hassan, Dr A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b364t-1fe92a2546072a4f92ef23ee57e4afba29775287f577ae82bdc6abd70a2a2dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Antiviral Agents - adverse effects</topic><topic>Chronic myeloid leukaemia, interferon-á, depression</topic><topic>Depression - chemically induced</topic><topic>Depression - complications</topic><topic>Depression - psychology</topic><topic>Health and Medicine</topic><topic>Humans</topic><topic>Interferon-alpha - adverse effects</topic><topic>Leukemia</topic><topic>Leukemia, Myeloid, Chronic-Phase - diagnosis</topic><topic>Leukemia, Myeloid, Chronic-Phase - drug therapy</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Mental disorders</topic><topic>Pharmaceuticals</topic><topic>Psychology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mamman, Aisha I</creatorcontrib><creatorcontrib>Yusuf, A.J</creatorcontrib><creatorcontrib>Aminu, Sm</creatorcontrib><creatorcontrib>Sheikh, T.L</creatorcontrib><creatorcontrib>Hassan, Dr A</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African health sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mamman, Aisha I</au><au>Yusuf, A.J</au><au>Aminu, Sm</au><au>Sheikh, T.L</au><au>Hassan, Dr A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe depression following á-interferon usage in a patient with chronic myeloid leukemia</atitle><jtitle>African health sciences</jtitle><addtitle>Afr Health Sci</addtitle><date>2009-03</date><risdate>2009</risdate><volume>9</volume><issue>1</issue><spage>54</spage><epage>56</epage><pages>54-56</pages><issn>1680-6905</issn><eissn>1729-0503</eissn><abstract>Background: Chronic myeloid leukaemia (CML), with a median age of 40
years, is one of the commonest haematological malignancies in Nigeria.
Cytoreductive agents, which were hitherto the mainstay of treatment,
neither induce cytogenetic nor haematologic remission. Alpha-interferon
(á-IFN), an endogenous glycoprotein with cytotoxic and natural
killer cell enhancer effects has been found to induce haematologic and
cytogenetic remission in patients with CML, but neuro- psychiatric
complications of á -interferon (á-IFN) usage were not
reported in Nigeria. Objective: To report a case of deliberate
self-harm in University Lecturer as a side effect of á-IFN in the
treatment of CML Method: Clinical and laboratory follow up of a
patient receiving á-IFN in the management of CML from the time of
diagnosis of CML to the point of loss of contact. Result: Severe
depression is a complication that may adversely influence the clinical
outcome of á-IFN usage Conclusions/Recommendations: Although
interferon related depression is uncommon, it is suggested that
pre-therapy interferon assays and neuro-psychiatric assessment are
carried out in prospective users of á-IFN</abstract><cop>Uganda</cop><pub>Makerere University Medical School</pub><pmid>20842244</pmid><tpages>3</tpages></addata></record> |
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| ispartof | African health sciences, 2009-03, Vol.9 (1), p.54-56 |
| issn | 1680-6905 1729-0503 |
| language | eng |
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| source | Open Access: PubMed Central |
| subjects | Adult Antiviral Agents - adverse effects Chronic myeloid leukaemia, interferon-á, depression Depression - chemically induced Depression - complications Depression - psychology Health and Medicine Humans Interferon-alpha - adverse effects Leukemia Leukemia, Myeloid, Chronic-Phase - diagnosis Leukemia, Myeloid, Chronic-Phase - drug therapy Male Medical treatment Mental disorders Pharmaceuticals Psychology Treatment Outcome |
| title | Severe depression following á-interferon usage in a patient with chronic myeloid leukemia |
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