Respiratory modulation of premotor cardiac vagal neurons in the brainstem

Abstract The respiratory and cardiovascular systems are highly intertwined, both anatomically and physiologically. Respiratory and cardiovascular neurons are often co-localized in the same brainstem regions, and this is particularly evident in the ventral medulla which contains presympathetic neuron...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2010-11, Vol.174 (1), p.102-110
Main Authors: Dergacheva, Olga, Griffioen, Kathleen J, Neff, Robert A, Mendelowitz, David
Format: Article
Language:English
Subjects:
Anatomy
Animals
Brain Stem - cytology
Brainstem
Cardiac vagal activity
Heart
Heart - physiology
Humans
Medical Education
Medulla Oblongata - physiology
Motor Neurons - physiology
Pulmonary/Respiratory
Respiration
Respiratory modulation
Vagus Nerve - physiology
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Summary:Abstract The respiratory and cardiovascular systems are highly intertwined, both anatomically and physiologically. Respiratory and cardiovascular neurons are often co-localized in the same brainstem regions, and this is particularly evident in the ventral medulla which contains presympathetic neurons in the rostral ventrolateral medulla, premotor parasympathetic cardioinhibitory neurons in the nucleus ambiguus, and the ventral respiratory group, which includes the pre-Botzinger complex. Anatomical studies of respiratory and cardiovascular neurons have demonstrated that many of these neurons have projections and axon collateral processes which extend into their neighboring cardiorespiratory regions providing an anatomical substrate for cardiorespiratory interactions. As other reports in this Special Issue of Respiratory Physiology & Neurobiology focus on interactions between the respiratory network and baroreceptors, neurons in the nucleus tractus solitarius, presympathetic neurons and sympathetic activity, this report will focus on the respiratory modulation of parasympathetic activity and the neurons that generate parasympathetic activity to the heart, cardiac vagal neurons.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2010.05.005