Expression of hepatocyte growth factor and its receptor c-Met in human pituitary adenomas

Hepatocyte growth factor (HGF) and its receptor c-Met have been known as key determinants of growth and angiogenesis in some brain tumors like gliomas, meningiomas, and schwannomas. But little is known about their expression in pituitary adenomas. In this study, the expression of HGF and c-Met in pi...

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Published in:Neuro-oncology (Charlottesville, Va.) Va.), 2010-08, Vol.12 (8), p.799-803
Main Authors: Hou, Xian-Zeng, Liu, Wei, Fan, Hai-Tao, Liu, Bin, Pang, Bo, Xin, Tao, Xu, Shang-Chen, Pang, Qi
Format: Article
Language:English
Subjects:
Adenoma - metabolism
Adenoma - pathology
Adult
Basic and Translational Investigations
Hepatocyte Growth Factor - biosynthesis
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Ki-67 Antigen - metabolism
Middle Aged
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Pituitary Neoplasms - metabolism
Pituitary Neoplasms - pathology
Proto-Oncogene Proteins c-met - biosynthesis
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Summary:Hepatocyte growth factor (HGF) and its receptor c-Met have been known as key determinants of growth and angiogenesis in some brain tumors like gliomas, meningiomas, and schwannomas. But little is known about their expression in pituitary adenomas. In this study, the expression of HGF and c-Met in pituitary adenomas of different histology types was investigated by immunohistochemistry, and correlative analysis of their expression with microvessel density (MVD), Ki-67 expression, and other clinicopathologic factors was made. The results showed that the expression of HGF and c-Met exists in 98% (64 of 65) and 92% (60 of 65) pituitary adenomas, respectively, and co-expression of them existed in 91% (59 of 65) adenomas. HGF had significant correlation with MVD (Spearman's correlation coefficient, r = .31, P = .01) and Ki-67 (r = .32, P = .01). c-Met had significant correlation with MVD (r = .30, P = .02) and Ki-67 (r = .38, P = .00). HGF and c-Met expression had no significant correlation with age or extrasellar extension. There were no significant differences in HGF and c-Met expression between pituitary adenomas of different histology types. The results indicate that HGF and c-Met are widely expressed in pituitary adenomas, and their expression correlates with MVD and Ki-67 expression.
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noq024