Relation of Serum Phosphorus Levels to Ankle Brachial Pressure Index (from the Third National Health and Nutrition Examination Survey)

Higher levels of serum phosphorus that remain within the reference range are associated with increased risk of cardiovascular disease (CVD). However, the mechanisms by which higher serum phosphorus concentrations may contribute to the development of CVD remain unclear. Cross-sectional association be...

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Bibliographic Details
Published in:The American journal of cardiology 2010-08, Vol.106 (4), p.564-568
Main Authors: Kendrick, Jessica, MD, Ix, Joachim H., MD, Targher, Giovanni, MD, Smits, Gerard, PhD, Chonchol, Michel, MD
Format: Article
Language:English
Subjects:
Adult
Adults
Aged
Ankle Brachial Index
Biological and medical sciences
Blood
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Demographics
Female
Humans
Logistic Models
Male
Medical sciences
Middle Aged
Nutrition Surveys
Phosphorus
Phosphorus - blood
Regression analysis
Risk factors
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Summary:Higher levels of serum phosphorus that remain within the reference range are associated with increased risk of cardiovascular disease (CVD). However, the mechanisms by which higher serum phosphorus concentrations may contribute to the development of CVD remain unclear. Cross-sectional association between serum phosphorus levels and arterial stiffness as estimated by an ankle brachial pressure index (ABPI) >1.3 was examined in 581 participants in the Third National Health and Nutrition Examination Survey. Logistic regression analysis was performed to evaluate whether higher serum phosphorus levels were associated with high ABPI, independently of several potential confounders. Of 581 participants, 38% and 10% had a serum phosphorus levels >3.5 and >4.0 mg/dl, respectively. An ABPI >1.3 was present in 7.3% of participants. Higher quartiles of serum phosphorus levels were associated with a greater prevalence of high ABPI: 5.4%, 3.7%, 7.8%, and 12.9% for quartiles 1 (
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2010.03.070