Transition-Metal-Free Catalytic Synthesis of 1,5-Diaryl-1,2,3-triazoles

1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2010-10, Vol.12 (19), p.4217-4219
Main Authors: Kwok, Sen W, Fotsing, Joseph R, Fraser, Rebecca J, Rodionov, Valentin O, Fokin, Valery V
Format: Article
Language:English
Subjects:
Catalysis
Hydroxides - chemistry
Molecular Structure
Transition Elements - chemistry
Triazoles - chemical synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol101568d