Challenges in Cardiac Tissue Engineering

Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of th...

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Published in:Tissue engineering. Part B, Reviews Reviews, 2010-04, Vol.16 (2), p.169-187
Main Authors: Vunjak-Novakovic, Gordana, Tandon, Nina, Godier, Amandine, Maidhof, Robert, Marsano, Anna, Martens, Timothy P., Radisic, Milica
Format: Article
Language:English
Subjects:
Animals
Cardiology
Care and treatment
Cellular biology
Electric Stimulation - methods
Heart - physiology
Heart diseases
Heart failure
Heart muscle
Heart Transplantation - methods
Heart Transplantation - physiology
Humans
Medical research
Models, Biological
Myocardium - cytology
Organ Culture Techniques
Perfusion - methods
Physiological aspects
Tissue engineering
Tissue Engineering - methods
Tissue Engineering - standards
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Summary:Cardiac tissue engineering aims to create functional tissue constructs that can reestablish the structure and function of injured myocardium. Engineered constructs can also serve as high-fidelity models for studies of cardiac development and disease. In a general case, the biological potential of the cell—the actual “tissue engineer”—is mobilized by providing highly controllable three-dimensional environments that can mediate cell differentiation and functional assembly. For cardiac regeneration, some of the key requirements that need to be met are the selection of a human cell source, establishment of cardiac tissue matrix, electromechanical cell coupling, robust and stable contractile function, and functional vascularization. We review here the potential and challenges of cardiac tissue engineering for developing therapies that could prevent or reverse heart failure.
ISSN:1937-3368
1937-3376
DOI:10.1089/ten.teb.2009.0352