Novel neoclerodane diterpene derivatives from the smoke of salvinorin A

Salvinorin A is a naturally occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by...

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Bibliographic Details
Published in:Tetrahedron letters 2010-09, Vol.51 (39), p.5207-5209
Main Authors: Ma, Zhongze, Deng, Gang, Lee, David Y.W.
Format: Article
Language:English
Subjects:
Neoclerodane diterpenoid
Opioid receptor
Salvinorin A
Smoke
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Summary:Salvinorin A is a naturally occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by spectroscopic methods. The major structural changes include epimerizations, eliminations, and rearrangements.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.07.144