Pegylated Interferon and Ribavirin Promote Early Evolution of Nonstructural 5A Protein in Individuals with Hepatitis C Who Demonstrate a Response to Treatment

BackgroundHepatitis C virus (HCV) quasispecies diversity is more likely to affect early viral decline during treatment of hepatitis C than is having human immunodeficiency virus (HIV) infection. We evaluated the influence of HCV therapy on changes in the nonstructural 5A (NS5A) protein MethodsFiftee...

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Bibliographic Details
Published in:The Journal of infectious diseases 2009-09, Vol.200 (6), p.866-876
Main Authors: Jain, Mamta K., Yuan, He-Jun, Adams-Huet, Beverley, Reeck, Amanda, Shelton, Janel, Attar, Nahid, Zhang, Song, Neumann, Avidan U., Carney, David S., Gale, Michael, Lee, William M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amino acids
Antiviral Agents - administration & dosage
Antiviral Agents - therapeutic use
Biological and medical sciences
Drug Therapy, Combination
Evolution
Evolution, Molecular
Fundamental and applied biological sciences. Psychology
Genotypes
Hepacivirus
Hepatitis C - drug therapy
Hepatitis C - virology
Hepatitis C virus
HIV
HIV Infections - complications
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Interferon alpha-2
Interferon-alpha - administration & dosage
Interferon-alpha - therapeutic use
Interferons
Kinetics
Medical sciences
Microbiology
Middle Aged
Molecular Sequence Data
Phylogeny
Polyethylene Glycols - administration & dosage
Polyethylene Glycols - therapeutic use
Proteins
Recombinant Proteins
Ribavirin - administration & dosage
Ribavirin - therapeutic use
RNA
RNA, Viral - genetics
Viral diseases
Viral hepatitis
Viral Nonstructural Proteins - genetics
Viruses
Young Adult
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Summary:BackgroundHepatitis C virus (HCV) quasispecies diversity is more likely to affect early viral decline during treatment of hepatitis C than is having human immunodeficiency virus (HIV) infection. We evaluated the influence of HCV therapy on changes in the nonstructural 5A (NS5A) protein MethodsFifteen patients with HCV genotype 1 infection with or without HIV infection were recruited for the present study, and the decrease in the HCV RNA level was measured at early time points. The evolution of HCV NS5A quasispecies within the first week was analyzed by comparing the clones observed at later times in the study with the baseline consensus sequence of individual patients. The response to therapy was defined as an early response (ER; ie, an HCV RNA level
ISSN:0022-1899
1537-6613
DOI:10.1086/605475