Interleukin 10 Gene Polymorphisms and Development of Post Kala-Azar Dermal Leishmaniasis in a Selected Sudanese Population

Background: Post kala-azar dermal leishmaniasis (PKDL) is a cutaneous form of disease that develops at variable times after individuals have received treatment for clinical visceral leishmaniasis (VL). The study aimed to investigate the possible role of interleukin 10 (IL-10) and development of PKDL...

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Published in:Community genetics 2010-01, Vol.13 (6), p.362-367
Main Authors: Farouk, S., Salih, M.A., Musa, A.M., Blackwell, J.M., Miller, E.N., Khalil, E.A., ElHassan, A.M., Ibrahim, M.E., Mohamed, H.S.
Format: Article
Language:English
Subjects:
Haplotypes
Humans
Interleukin-10 - genetics
Leishmaniasis, Cutaneous - epidemiology
Leishmaniasis, Cutaneous - genetics
Leishmaniasis, Cutaneous - pathology
Leishmaniasis, Visceral - epidemiology
Leishmaniasis, Visceral - genetics
Leishmaniasis, Visceral - pathology
Minority & ethnic groups
Original Paper
Polymorphism, Genetic
Sudan - epidemiology
Vector-borne diseases
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Summary:Background: Post kala-azar dermal leishmaniasis (PKDL) is a cutaneous form of disease that develops at variable times after individuals have received treatment for clinical visceral leishmaniasis (VL). The study aimed to investigate the possible role of interleukin 10 (IL-10) and development of PKDL. Methods: 77 families composed of 41 complete case-parent trios and 36 case-parent pairs from the Masalit ethnic group were genotyped for 3 IL10 promoter polymorphisms: -1082A/G, -819C/T and -592C/A. Results: Single point analysis using the transmission disequilibrium test showed no evidence of association between any of these IL10 promoter single nucleotide polymorphisms (SNPs) and development of PKDL. Haplotype analysis performed using TRANSMIT showed borderline significance between PKDL and the haplotype AA across -592C/A and -1082A/G (p = 0.053). Haplotypes GCC (0.33) and ATA (0.30) were the common haplotypes in this Sudanese population. Allele frequencies for the 3 SNPs differed significantly in Sudan compared to other African (Gambian, Malawian, YRI) populations. Conclusion: There is no evidence for an association between 3 SNPs in the IL10 gene promoter and susceptibility to PKDL in the Masalit ethnic group in Sudan, although some evidence for haplotype association was observed.
ISSN:1662-4246
1662-8063
DOI:10.1159/000272457