Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents

• Published in: Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-10
• Main Authors: Lakmichi, Hind, Bakhtaoui, Fatima Zahra, Gadhi, Chemseddoha A., Ezoubeiri, Aicha, El Jahiri, Younes, El Mansouri, Abdellah, Zrara, Ibtissam, Loutfi, Kenza
• Format: Article
• Language: English
• Subjects: Acute toxicity; Alkaline phosphatase; Alternative medicine; Brassica oleracea; Caryophyllaceae; Corrigiola; Creatinine; Drug dosages; Enzymes; Ethanol; Food; Gender differences; Glycoproteins; Hepatotoxicity; Herbal medicine; Laboratory animals; Males; Medical research; Medicinal plants; Pharmacology; Phosphorus; Phytochemicals; Rats; Rodents; Sodium; Toxicology; γ-Glutamyltransferase
• ISSN: 1741-427X; 1741-4288; 1741-4288; 1741-427X
• DOI: 10.1155/2011/317090

Corrigiola telephiifolia Pourr. (Caryophyllaceae) is a Moroccan medicinal plant. Despite its popular usage, no study has been published concerning its toxicological profile. The acute toxicity of C. telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000, and 14000 mg/kg bodyweight. The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study. No mortality or signs of toxicity were observed in the acute study. In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex. At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P