Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents

Corrigiola telephiifolia Pourr. (Caryophyllaceae) is a Moroccan medicinal plant. Despite its popular usage, no study has been published concerning its toxicological profile. The acute toxicity of C. telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000,...

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Published in:Evidence-based complementary and alternative medicine 2011-01, Vol.2011 (2011), p.1-10
Main Authors: Lakmichi, Hind, Bakhtaoui, Fatima Zahra, Gadhi, Chemseddoha A., Ezoubeiri, Aicha, El Jahiri, Younes, El Mansouri, Abdellah, Zrara, Ibtissam, Loutfi, Kenza
Format: Article
Language:English
Subjects:
Acute toxicity
Alkaline phosphatase
Alternative medicine
Brassica oleracea
Caryophyllaceae
Corrigiola
Creatinine
Drug dosages
Enzymes
Ethanol
Food
Gender differences
Glycoproteins
Hepatotoxicity
Herbal medicine
Laboratory animals
Males
Medical research
Medicinal plants
Pharmacology
Phosphorus
Phytochemicals
Rats
Rodents
Sodium
Toxicology
γ-Glutamyltransferase
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description Corrigiola telephiifolia Pourr. (Caryophyllaceae) is a Moroccan medicinal plant. Despite its popular usage, no study has been published concerning its toxicological profile. The acute toxicity of C. telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000, and 14000 mg/kg bodyweight. The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study. No mortality or signs of toxicity were observed in the acute study. In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex. At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P
doi_str_mv 10.1155/2011/317090
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The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study. No mortality or signs of toxicity were observed in the acute study. In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex. At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P&lt;.05). At the dose of 2000 mg/kg/day, the extract significantly increased the serum concentrations of creatinine, alkaline phosphatase, gamma-glutamyltransferase and phosphorus (P&lt;.05) all suggestive of functional nephrotoxicity and hepatotoxicity. The relative bodyweight of both sexes decreased at the dose of 2000 mg/kg/day, with a fast recovery for males. Histological examination did not reveal any treatment-related effects. In conclusion, Corrigiola extract appears safe at the doses used ethno-medicinally. 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subjects Acute toxicity
Alkaline phosphatase
Alternative medicine
Brassica oleracea
Caryophyllaceae
Corrigiola
Creatinine
Drug dosages
Enzymes
Ethanol
Food
Gender differences
Glycoproteins
Hepatotoxicity
Herbal medicine
Laboratory animals
Males
Medical research
Medicinal plants
Pharmacology
Phosphorus
Phytochemicals
Rats
Rodents
Sodium
Toxicology
γ-Glutamyltransferase
title Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents
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