Mitochondrial SIRT3 and heart disease

Sirtuins are emerging as key regulators of many cellular functions including metabolism, cell growth, apoptosis, and genetic control of ageing. In mammals there are seven sirtuin analogues, SIRT1 to SIRT7. Among them SIRT3 is unique because this is the only analogue whose increased expression has be...

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Bibliographic Details
Published in:Cardiovascular research 2010-11, Vol.88 (2), p.250-256
Main Authors: Pillai, Vinodkumar B., Sundaresan, Nagalingam R., Jeevanandam, Valluvan, Gupta, Mahesh P.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biological and medical sciences
Cardiac hypertrophy
Cardiology. Vascular system
Cardiomegaly - enzymology
Cardiomegaly - prevention & control
Energy Metabolism
Errors of metabolism
Heart Diseases - enzymology
Heart Diseases - pathology
Heart Diseases - prevention & control
Humans
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
Mitochondria, Heart - enzymology
Mitochondria, Heart - pathology
Mitochondrial metabolism
Myocardium - enzymology
Myocardium - pathology
Reactive Oxygen Species - metabolism
Reviews: Focus on Mitochondria in Cardiac Disease
SIRT3
Sirtuin 3 - metabolism
Sirtuins
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Summary:Sirtuins are emerging as key regulators of many cellular functions including metabolism, cell growth, apoptosis, and genetic control of ageing. In mammals there are seven sirtuin analogues, SIRT1 to SIRT7. Among them SIRT3 is unique because this is the only analogue whose increased expression has been found to be associated with extended lifespan of humans. SIRT3 levels have been shown to be elevated by exercise and calorie restriction. Although the role of SIRT3 in cell biology is only beginning to be understood, initial studies have shown that SIRT3 plays a major role in free fatty acid oxidation and maintenance of cellular ATP levels. In the heart SIRT3 has been found to block development of cardiac hypertrophy and protect cardiomyocytes from oxidative stress-mediated cell death. Similarly, SIRT3 has been reported to have tumour-suppressive characteristics. In this article, we review the known effects of SIRT3 in different tissues and relate them to the protection of cardiomyocytes under stress.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/cvq250