Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy

Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation,...

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Published in:The American journal of cardiology 2010-08, Vol.106 (3), p.360-368
Main Authors: Turer, Aslan T., MD, MHS, Hill, Joseph A., MD, PhD
Format: Article
Language:English
Subjects:
Cardiac Surgical Procedures - adverse effects
Cardiology
Cardiovascular
Heart Arrest, Induced - adverse effects
Humans
Ischemia
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Pathogenesis
Risk Factors
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container_title The American journal of cardiology
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creator Turer, Aslan T., MD, MHS
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description Since the initial description of the phenomenon by Jennings et al 50 years ago, our understanding of the underlying mechanisms of reperfusion injury has grown significantly. Its pathogenesis reflects the confluence of multiple pathways, including ion channels, reactive oxygen species, inflammation, and endothelial dysfunction. The purposes of this review are to examine the current state of understanding of ischemia-reperfusion injury, as well as to highlight recent interventions aimed at this heretofore elusive target. In conclusion, despite its complexity our ongoing efforts to mitigate this form of injury should not be deterred, because nearly 2 million patients annually undergo either spontaneous (in the form of acute myocardial infarction) or iatrogenic (in the context of cardioplegic arrest) ischemia-reperfusion.
doi_str_mv 10.1016/j.amjcard.2010.03.032
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source ScienceDirect Journals
subjects Cardiac Surgical Procedures - adverse effects
Cardiology
Cardiovascular
Heart Arrest, Induced - adverse effects
Humans
Ischemia
Myocardial Infarction - physiopathology
Myocardial Infarction - therapy
Myocardial Reperfusion Injury - physiopathology
Myocardial Reperfusion Injury - prevention & control
Pathogenesis
Risk Factors
title Pathogenesis of Myocardial Ischemia-Reperfusion Injury and Rationale for Therapy
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