Risk factors for chronic hepatitis B virus infection among blood donors in Bangalore, India

Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India. Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg...

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Bibliographic Details
Published in:Transfusion medicine (Oxford, England) England), 2010-12, Vol.20 (6), p.414-420
Main Authors: Jagannathan, L., Chaturvedi, M., Mudaliar, S., Kamaladoss, T., Rice, M., Murphy, E. L.
Format: Article
Language:English
Subjects:
Adult
Barbering
Blood donors
Blood Donors - statistics & numerical data
Chronic infection
Cohort Studies
Environmental Exposure
Female
haematology
Hepatitis B virus
Hepatitis B, Chronic - epidemiology
Humans
India - epidemiology
Male
Middle Aged
Risk Factors
Risk-Taking
Rural Population
Socioeconomic Factors
Surveys and Questionnaires
Volunteers
Young Adult
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Summary:Objectives and Aim: We performed a study of hepatitis B virus (HBV) risk factors among blood donors in Bangalore, India. Background: HBV infection is prevalent in India and poses a potential risk of transmission by blood transfusion, but studies of risk factors for hepatitis B surface antigen (HBsAg) carriage among Indian blood donors are lacking. Methods/Materials: Using a case‐cohort design, we enrolled 71 cases with repeatedly reactive HBsAg results and a cohort of 212 contemporaneous blood donors with unknown HBsAg status. Questionnaire data were analysed using multivariable logistic regression. Results: In our multivariate analysis controlling for age, HBsAg positivity was associated with repeat donor status (OR = 0·34, 95% CI 0·17–0·71 vs first‐time donor status), residence outside Bangalore and Hosur (rural areas) (OR = 15·66, 95% CI 3·60–68·07vs Bangalore residence), having been a customer at a local barber shop (OR = 4·07, 95% CI 2·06–8·03), close contact with a person who had jaundice (OR = 13·64, 95% CI 3·71–50·24) and cigarette smoking (OR = 3·25, 95% CI 1·39–7·60). Conclusion: In addition to recognised demographic risk factors, associations with patronage of local barbers and contact with jaundiced individuals suggest behavioural risk factors that could be adopted as exclusionary criteria for blood donation in India.
ISSN:0958-7578
1365-3148
DOI:10.1111/j.1365-3148.2010.01032.x