Dendritic growth in medial prefrontal cortex and cognitive flexibility are enhanced during the postpartum period

The postpartum period is associated with numerous hormonal changes, some of which have been linked to detrimental effects on the medial prefrontal cortex (mPFC), a brain region involved in cognition. Here, we investigated whether mPFC structure and function are negatively influenced during the postp...

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Bibliographic Details
Published in:The Journal of neuroscience 2010-10, Vol.30 (40), p.13499-13503
Main Authors: Leuner, Benedetta, Gould, Elizabeth
Format: Article
Language:English
Subjects:
Animals
Brief Communications
Cell Differentiation - physiology
Cognition - physiology
Dendrites - physiology
Female
Neuronal Plasticity - physiology
Postpartum Period - physiology
Prefrontal Cortex - cytology
Prefrontal Cortex - physiology
Pregnancy
Psychomotor Performance - physiology
Pyramidal Cells - cytology
Pyramidal Cells - physiology
Rats
Rats, Sprague-Dawley
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Summary:The postpartum period is associated with numerous hormonal changes, some of which have been linked to detrimental effects on the medial prefrontal cortex (mPFC), a brain region involved in cognition. Here, we investigated whether mPFC structure and function are negatively influenced during the postpartum period, an outcome that might be predicted by the maternal hormonal milieu. Mother rats were tested on an attentional set-shifting task, and dendritic architecture of layer 2/3 mPFC pyramidal neurons was analyzed. Mother rats exhibited increased dendritic spine number in the mPFC, an effect that coincided with improved attention and behavioral flexibility. These findings suggest that the postpartum period is associated with promotion of neuronal growth in the mPFC and enhanced cognitive function.
ISSN:0270-6474
1529-2401
DOI:10.1523/jneurosci.3388-10.2010